SURVIVAL OF PLATELET DENSITY SUBPOPULATIONS
نویسندگان
چکیده
منابع مشابه
Heterogeneity of Human Whole Blood Platelet Subpopulations
A quantitative high yield method utilizing isosmotic arabino-galactan (Stractan) solutions and isopycnic centrifugation was developed to isolate and to fractionate total human platelet populations into density-dependent subpopulations. Isolated platelets were free of factor VIll/von Willebrand factor and other plasma proteins. They responded to ADP, epinephrine, and collagen with a sensitivity ...
متن کاملHeterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure.
A quantitative high yield method utilizing isosmotic arabino-galactan (Stractan) solutions and isopycnic centrifugation was developed to isolate and to fractionate total human platelet populations into density-dependent subpopulations. Isolated platelets were free of factor VIII/von Willebrand factor and other plasma proteins. They responded to ADP, epinephrine, and collagen with a sensitivity ...
متن کاملHeterogeneity of human whole blood platelet subpopulations. III. Density-dependent differences in subcellular constituents.
Structurally intact platelet cohorts of differing densities can be isolated from normal subjects by the use of isosmolar arabinogalactan density gradients. Using platelets separated in this fashion, we have studied the density-dependent distribution of four subcellular organelles: mitochondria, lysosomes, dense bodies, and alpha granules. Mitochondria, which are not secreted during platelet rel...
متن کاملThe relation of platelet density to platelet age: survival of low- and high-density 111indium-labeled platelets in baboons.
The relationship between platelet density and platelet age has been studied using continuous linear Percoll density gradients and 111In-labeling of autologous platelets in baboons. To investigate changes in platelet density during senescence in the circulation, baboons were infused with 111In-labeled autologous platelets, and blood was collected at one hour postinfusion and twice daily thereaft...
متن کاملPlatelet heterogeneity: variation in coagulation complexes on platelet subpopulations.
OBJECTIVE Previous work has shown that platelets stimulated with the combination of thrombin and convulxin, a glycoprotein VI agonist, develop 2 populations with different levels of alpha-granule factor V bound to the platelet surface. To evaluate whether this phenomenon is restricted to alpha-granule components or is a feature that can be generalized to other coagulation factors, we studied th...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1987
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.1987.tb04167.x